Antioxidative and in vitro antiproliferative activity of Arctium lappa root extracts

Doi: 10.1186/1472-6882-11-25

Fabricia S Predes,¹Ana LTG Ruiz,²João E Carvalho,²Mary A Foglio,¹ and Heidi Dolder¹

Published online 2021 May 31

Abstract

Background

Arctium lappa, known as burdock, is widely used in popular medicine for hypertension, gout, hepatitis and other inflammatory disorders. Pharmacological studies indicated that burdock roots have hepatoprotective, anti-inflammatory, free radical scavenging and antiproliferative activities. The aim of this study was to evaluate total phenolic content, radical scavenging activity by DPPH and in vitro antiproliferative activity of different A. lappa root extracts.

Methods

Hot and room temperature dichloromethanic, ethanolic and aqueous extracts; hydroethanolic and total aqueous extract of A. lappa roots were investigated regarding radical scavenging activity by DPPH, total phenolic content by Folin-Ciocalteau method and antiproliferative in vitro activity was evaluated in human cancer cell lines. The hydroethanolic extract analyzed by high-resolution electrospray ionization mass spectroscopy.

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References:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3073957/