•  doi: 10.1002/fsn3.2701
• Published online 2022 Jan 22

PatriciaRodrigues Orsi^aFláviaBonamin^bJulianaAparecida Severi^aRaquelCássia Santos^bWagnerVilegas^cdClélia AkikoHiruma-Lima^b1Luiz Claudio DiStasi^a1aUniv. Estadual Paulista-UNESP – Departamento de Farmacologia, Instituto de Biociências, CEP 18618-000, Botucatu, SP, Brazil^bUniv. Estadual Paulista-UNESP – Departamento de Fisiologia, Instituto de Biociências, CEP 18618-970, Botucatu, SP, Brazil^cUniv. Estadual Paulista-UNESP – Campus Experimental do Litoral Paulista, CEP 11330-900, São Vicente, SP, Brazil^dUniv. Estadual Paulista-UNESP – Departamento de Química Organica, Instituto de Química, CEP 14801-970, Araraquara, SP, Brazil

Abstract

Jiaogulan (Gynostemma pentaphyllum) is a traditional Chinese medicinal herb that has been widely used in food and supplemental products. In the last 20 years, extensive research has been conducted to investigate the medicinal prospects of jiaogulan, and in this regard, more than 200 compounds have been isolated with various medicinal properties such as anticancer, anti‐obesity, anti‐inflammation, and antioxidation. In respect of potential benefits, jiaogulan market is likely growing, and various food items comprised of jiaogulan (beverage, sport drinks, cola, beer, tea, bread, and noodles) have been commercialized in the United States of America, China, and other Asian countries. More recently, there has been growing interest in the prebiotic potential of jiaogulan, especially at the interface of the gut microbiota. This review focuses on the prebiotic and therapeutic aspects of saponins and polysaccharides of jiaogulan tea by summarizing the literature on cancer, obesity, antioxidant activity, and immune‐modulatory properties.

Keywords: gut microbiota, Gynostemma pentaphyllum (jiaogulan), polysaccharides, saponins

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Abstract

This study summarizes the therapeutic and prebiotic properties of various saponins and polysaccharides from jiaogulan. The study also highlights gut microbiota (GM)‐modulating properties of various compounds from jiaogulan. This review highlights the therapeutic effect of jiaogulan on the diversity and composition of GM.

1. INTRODUCTION

Gynostemma pentaphyllum Makino (Cucurbitaceae; Gp) is a perennial creeping plant and has been used for herbal tea (called jiaogulan) in China. For centuries, the herbal tea made from the aerial part (including stems and leaves) of Gp has been consumed in China as a general tonic. Today, it is progressively popularizing around the world for lowering serum lipid and cholesterol levels (Chen et al., ¹⁹⁹¹; Lin et al., ²⁰⁰⁰). Like green tea, jiaogulan tea also holds anticarcinogenic and antioxidative activities (Lin et al., ²⁰⁰⁰; Razmovski‐Naumovski et al., ²⁰⁰⁵). Increasing research interest in Gp is evident from a search of the PubMed database (Figure 1)

Reference:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8907712/