• https://doi.org/10.1016/j.jep.2012.06.001
• 30 August 2012

PatriciaRodrigues Orsi^aFláviaBonamin^bJulianaAparecida Severi^aRaquelCássia Santos^bWagnerVilegas^cdClélia AkikoHiruma-Lima^b1Luiz Claudio DiStasi^a1aUniv. Estadual Paulista-UNESP – Departamento de Farmacologia, Instituto de Biociências, CEP 18618-000, Botucatu, SP, Brazil^bUniv. Estadual Paulista-UNESP – Departamento de Fisiologia, Instituto de Biociências, CEP 18618-970, Botucatu, SP, Brazil^cUniv. Estadual Paulista-UNESP – Campus Experimental do Litoral Paulista, CEP 11330-900, São Vicente, SP, Brazil^dUniv. Estadual Paulista-UNESP – Departamento de Química Organica, Instituto de Química, CEP 14801-970, Araraquara, SP, Brazil

Abstract

Ethnopharmacological relevance

Hymenaea stigonocarpa Mart. ex Hayne (Fabaceae) is a medicinal species commonly found in the Brazilian savannah. The stem bark of this medicinal plant, popularly known as “jatobá-do-cerrado”, is widely used in tea form to treat gastric pain, ulcers, diarrhoea and inflammation, whereas its fruits pulp is edible.

Aim of the study

The aim of this study was to investigate the antidiarrheal and anti-ulcer effects of a methanolic extract derived from the stem bark (MHs) and diet with fruit pulp of H. stigonocarpa.

Materials and methods

The antidiarrheal action of MHs was measured against the intestinal motility and diarrhoea induced by castor oil in mice. The preventive action of MHs (50, 100, 150 and 200 mg/Kg, by oral route (p.o.)) against peptic ulcers was evaluated in experimental rodent models challenged with absolute ethanol, non-steroidal anti-inflammatory drugs (NSAIDs), ischemia–reperfusion (I/R) (200 mg/Kg, p.o.) and cysteamine (200 mg/Kg, p.o.). The main anti-ulcer mechanisms of action of MHs were analysed as follows: evaluation of the gastric juice parameters, assessment of mucus adherence to the gastric wall, determination of the role of nitric oxide (NO) and sulfhydryl compounds (SH), glutathione (GSH) levels and myeloperoxidase (MPO) activity. The healing effects from MHs (200 mg/Kg) and diet with fruit pulp (10%) against gastric and duodenal ulcers induced by acetic acid were also evaluated by treating rats over 7 or 14 consecutive days of treatment.

Reference:

https://www.sciencedirect.com/science/article/pii/S0378874112003881